Drug discovery and development are aimed at identifying new chemical molecular entities (NCEs) with desirable pharmacokinetic profiles for high therapeutic efficacy.The plasma concentrations of NCEs are a biomarker of their efficacy and are governed by pharmacokinetic processes such as absorption, distribution, metabolism, and excretion Reinwassers
The Effect of Behavioural Indicators of Calf Discomfort Following Routine Procedures on Cow Maternal Care
Pain causes altered arousal and specific behaviours that are rare at other times (pain indicators).We examined whether beef cows (mean age 6 years) are sensitive to pain indicators in addition to arousal following ear tagging and rubber ring castration (males only, n = 31) of their calf (n = 58).Behavioural pain indicators and activity were recorde
Carcinoid tumour of appendix in a child: A rare case at an uncommon site
Carcinoid tumours of the appendix are uncommon incidentally detected tumours during histopathological examination following appendicectomy for acute appendicitis.Even though considered rare in children, they are the most frequently encountered tumours of the Vegetable / Fruit Wedger Parts gastrointestinal tract.To our knowledge, carcinoid tumour of
Investigating the operation mechanism of light-emitting electrochemical cells through operando observations of spin states
Abstract Light-emitting electrochemical cells (LECs) are next-generation devices that are flexible, emit light and have several advantages over organic light-emitting MAKEUP diodes, such as a simpler structure and lower cost.However, the operation mechanism of LECs remains unknown from a microscopic viewpoint.Here, we perform an operando microscopi